Welcome to Zhengqing Ouyang's lab homepage. Our lab is part of The Jackson Laboratory for Genomic Medicine, and is affiliated with University of Connecticut Institute for Systems Genomics, Department of Genetics and Genome Sciences, and Department of Biomedical Engineering. We are located on the campus of University of Connecticut Health Center.
The Ouyang lab is focused on decoding regulatory information from genomic big data. We have developed statistical and
computational methodologies to reconstruct 3D genome structures (Genome Biology 2016), RNA structuromes (Genome Research 2013, Nucleic Acids Research 2015), and regulomes (PNAS 2009, AOAS 2017). We have used our approaches to unveil genetic and epigenetic mechanisms of human development and diseases.
04/2017 - Our paper A statistical framework for data integration through graphical models with application to cancer genomics has
been published in Annals of Applied Statistics!
07/2016 - Prof. Ouyang has received the Pharmaceutical Research and Manufacturers of America (PhRMA) Foundation Award at the 24th Annual International Conference on Intelligent Systems for Molecular Biology (ISMB 2016) in Orlando, Florida!
05/2016 - Chenchen has attended The Whole Scientist™ workshop in Bar Harbor, Maine with travel fellowship!
04/2016 - Chenchen has attended the 20th Annual International Conference on Research in Computational Molecular Biology (RECOMB 2016) in Santa Monica, California with travel fellowship!
03/2016 - Our paper HSA: integrating multi-track Hi-C data for genome-scale reconstruction of 3D chromatin structure has
been published in Genome Biology!
02/2016 - Our research is featured by The Search Magazine!
12/2015 - We are awarded the Pharmaceutical Research and Manufacturers of America (PhRMA) Foundation Research Starter Grant in Informatics!
09/2015 - Our research is highlighted by The Jackson Laboratory news!
09/2015 - Our paper joint modeling of RNase footprint sequencing profiles for genome-wide inference of RNA structure has been published in Nucleic Acids Research!
08/2015 - Chenchen has attended the Joint Statistical Meetings in Seattle, Washington with travel fellowship!
07/2015 - Jianan and Chenchen have attended the 56th Annual Short Course on Medical and Experimental Mammalian Genetics in Bar Harbor, Maine with travel fellowships!
03/2015 - Jianan has won the Tie for the second place in poster competition of the BME Department at UConn!
03/2015 - Chenchen has attended the Bioinformatics: Statistical Modeling and Analysis of Whole Genome Methylation and Chromatin Interaction (Epigenetics) workshop in Research Triangle Park, North Carolina with travel fellowship!
12/2014 - Our paper predicting quantitative outcomes of patients using longitudinal gene expression has been published in Sri Lankan Journal of Applied Statistics Special Issue: "Modern Statistical Methodologies in the Cutting Edge of Science"!
11/2014 - Our lab has been affiliated with the Institute for Systems Genomics at UConn!
10/2014 - We are moving to our gorgeous new building!
08/2014 - Chenchen has attended the Joint Statistical Meetings in Boston, Massachusetts with travel fellowship!
03/2014 - Chenchen has attended The Whole Scientist™ workshop in Bar Harbor, Maine with travel fellowship!
01/2014 - Prof. Ouyang is featured by The Jackson Laboratory news!
01/2014 - Our paper landscape and variation of RNA secondary structure across the human transcriptome has been published in Nature!
12/2013 - Prof. Ouyang has been awarded the Genome Technology Young Investigators of the Year Award!
10/2013 - Our paper STAT3 targets on aggressive tumorigenesis in diffuse large B cell lymphoma has been published in G3: Genes, Genomes, Genetics!04/2013 - Our paper RNA structure mapping using nuclease digestion and high-throughput sequencing has been published in Nature Protocols!
03/2013 - Our lab has been affiliated with the Department of Genetics and Genome Sciences at the University of Connecticut School of Medicine!
01/2013 - Our paper genome-scale computational RNA secondary structure reconstruction has been published in Genome Research!
01/2013 - Our lab has been affiliated with the Department of Biomedical Engineering at the University of Connecticut School of Engineering!
12/2012 - Prof. Ouyang is featured by The Jackson Laboratory news!