Welcome to Zhengqing Ouyang's lab homepage. Our lab is part of The Jackson Laboratory for Genomic Medicine, and is affiliated with University of Connecticut Institute for Systems Genomics, Department of Genetics and Genome Sciences, and Department of Biomedical Engineering. We are located on the campus of University of Connecticut Health Center.
We are focused on understanding the higher-order architectures (in 2D, 3D, and 4D) of
the genome and the transcriptome, i.e., the epigenome and the epitranscriptome. We develop statistical and computational
methodologies for analyzing high-throughput
sequencing data (ChIP-seq, Hi-C, ChIA-PET, RNase-seq, icSHAPE, etc). Our methods, such as TFAS (PNAS 2009), SeqFold (Genome Research 2013), JGM-HMM (Nucleic Acids Research 2015), and HSA (Genome Biology
2016), have advanced the elucidation of the regulatory genome (the regulome). We haved used
methods to dissect the structure and functions of chromatin and RNA, to
unravel the regulatory code of biological processes, and to identify
genetic and epigenetic mechanisms of human
05/2016 - Chenchen has attended The Whole Scientist™ workshop in Bar Harbor, Maine, with travel fellowship!
04/2016 - Chenchen has attended the 20th Annual International Conference on Research in Computational Molecular Biology (RECOMB 2016) in Santa Monica, California, with oral presentation titled multi-track modeling for genome-scale reconstruction of 3D chromatin structure from Hi-C data!
03/2016 - Our paper HSA: integrating multi-track Hi-C data for genome-scale reconstruction of 3D chromatin structure has
been published in Genome Biology!
02/2016 - Our research is featured by The Search Magazine!
12/2015 - We are awarded the PhRMA Foundation Research Starter Grant in Informatics!
09/2015 - Our research is highlighted by The Jackson Laboratory news!
09/2015 - Our paper joint modeling of RNase footprint sequencing profiles for genome-wide inference of RNA structure has been published in Nucleic Acids Research!
08/2015 - Chenchen has attended the Joint Statistical Meetings in Seattle, Washington, with travel fellowship!
07/2015 - Jianan and Chenchen have attended the 56th Annual Short Course on Medical and Experimental Mammalian Genetics in Bar Harbor, Maine, with travel fellowships!
03/2015 - Jianan has won the tie for the second place in poster competition of the BME Department at UConn!
03/2015 - Chenchen has attended the Bioinformatics: Statistical Modeling and Analysis of Whole Genome Methylation and Chromatin Interaction (Epigenetics) workshop in Research Triangle Park, North Carolina, with travel fellowship!
12/2014 - Our paper predicting quantitative outcomes of patients using longitudinal gene expression has been published in Sri Lankan Journal of Applied Statistics Special Issue: "Modern Statistical Methodologies in the Cutting Edge of Science"!
11/2014 - Our lab has been affiliated with the Institute for Systems Genomics at UConn!
10/2014 - We are moving to our gorgeous new building!
08/2014 - Chenchen has attended the Joint Statistical Meetings in Boston, Massachusetts, with travel fellowship!
03/2014 - Chenchen has attended The Whole Scientist™ workshop in Bar Harbor, Maine, with travel fellowship!
01/2014 - Prof. Ouyang is featured by The Jackson Laboratory news!
01/2014 - Our paper landscape and variation of RNA secondary structure across the human transcriptome has been published in Nature!
12/2013 - Prof. Ouyang has been awarded the Genome Technology Young Investigators of the Year Award!
10/2013 - Our paper STAT3 targets on aggressive tumorigenesis in diffuse large B cell lymphoma has been published in G3: Genes, Genomes, Genetics!04/2013 - Our paper RNA structure mapping using nuclease digestion and high-throughput sequencing has been published in Nature Protocols!
03/2013 - Our lab has been affiliated with the Department of Genetics and Genome Sciences at the University of Connecticut School of Medicine!
01/2013 - Our paper genome-scale computational RNA secondary structure reconstruction has been published in Genome Research!
01/2013 - Our lab has been affiliated with the Department of Biomedical Engineering at the University of Connecticut School of Engineering!
12/2012 - Prof. Ouyang is featured by The Jackson Laboratory news!